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| We think some of the novel synthetic compounds will get around the shortcomings of curcumin and improve the therapeutic efficacy, Cashman said. The team discovered that curcuminoids enhanced the surface binding of amyloid beta to macrophages and that vitamin D strongly stimulated the uptake and absorption of amyloid beta in macrophages in a majority of patients. Previous research by the team demonstrated that the immune genes MGAT III and TLR-3 are associated with the immune system's ability to better ingest amyloid beta. In this earlier work, Fiala noted, it was shown that there are two types of Alzheimer's patients: Type 1 patients, who respond positively to curcuminoids, and Type II patients, who do not.
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Since vitamin D and curcumin work differently with the immune system, we may find that a combination of the two or each used alone may be more effective - depending on the individual patient, he said. Fiala noted that this is early laboratory research and that no dosage of vitamin D or curcumin can be recommended at this point. Larger vitamin D and curcumin studies with more patients are planned. The study was funded by the Human BioMolecular Research Institute, the Alzheimer's Association and MP Biomedicals LLC, a global life sciences and diagnostics company dedicated to Alzheimer's disease research. Fiala is a consultant for MP Biomedicals and also served in the company's speakers bureau. Additional study authors include Ava Masoumi, Ben Goldenson, Hripsime Avagyan, Justin Zaghi, Michelle Mahanian, Martin Hewison, Araceli Espinosa-Jeffrey and Phillip T.
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